Unfortunately, there isn't enough place between the individual PCB layouts in that panel for using something like a saw.
Hmm... the PCBs have 4 layers, and the two inner layers are GND and VCC supply layers.
After "breaking" the panel into four PCBs "somehow" and "deburring" the edges of the PCBs,
maybe it would be a good idea to check for a short circuit between the supply layers before soldering starts...
Sandpaper (which comes in different grit sizes) also could be used for "deburring" the edge of a PCB.
// The trick is to move the PCB, not the sandpaper.
I had a quick look and noticed some vias were uncovered (I specified tented vias). That may prove to be a problem, since some of these vias are quite close to adjacent pads and I may bridge them when soldering.
When covering/protecting the IC pads on the PCB with paper or cardboard, maybe you could try to paint those uncovered vias
which are too close to the IC pads with green nail polish or such.
Protecting the IC pads on the PCB with transparent tesa tape (tm) while painting probably would leave some glue on those IC pads...
...what won't simplify soldering the ICs later.