I'll add my welcome also, and my $0.02.
In addition to everything else that's been said, I'll 4th or 5th the initial serial connection route. I've been using the FTDI UART-USB adapters for many years. I prefer these as they have drivers for OSX, Windoze and Linux. Many folks have done the same and also opted to power their creation via USB. I've opted not to use USB for power. My reason is simple, I prefer a separate power supply as I can easily disconnect the SBC from the USB port on my laptop and let it continue running. It's also nice in case you have an accidental connection issue. Here's once I've been using, albeit on the pricey side (it's a DB9 housing):
https://www.mouser.com/ProductDetail/FT ... yVDNan4%3D Parts selection and sourcing becomes another area I would make stronger recommendations in. We've (forum in general) had numerous folks that have already sourced 6502 related parts from sketchy sources before finding 6502.org, only to realize that the might have gotten a counterfeit part or one that wasn't exactly what they thought it was. So my personal recommendation is to source a new WDC W65C02S CPU and buy new memory and logic chips from a current supplier like Mouser. Many folks out here have their "go to" sources for many different parts, but if you're new to this hardware area, stick with current new production parts and save yourself a lot of time and hassle.
For a UART, the current WDC W65C51N has a bug, so I wouldn't recommend using it. The current view is to use one of the NXP UARTs or DUARTs which are readily available and easily interfaced to a 65C02. I've used the SCC2691 in my recent SBC and BDD has written a nice document on getting the newer NXP DUARTs to work, so that's worth reading as well.
Lastly (for now), I would recommend looking at some others' existing projects. This will give you some perspective on hardware design and also some software to make them work. I'd also consider a small PLD (like a 22V10 GAL) for a single glue logic, albeit perhaps wait for a second breadboard version. I'd also recommend getting a breadboard machine running first... then once you're happy with it, consider making a PCB for it.
In all cases... focus on having fun while doing this!