Perhaps I'm confused because I was thinking of most commercially available 4GB RAM chips.
Ah, I see: you were thinking of a particular implementation. More generally: we'll have 32 address lines, and 16 data lines, and so the memory subsystem can hang enough chips off those lines to give us 2^32 words of 16 bits each, however many chips that takes.
In practice, as EE suggests, and certainly at this stage, we'll usually see much less memory than that.
But if we happen to install more than 16MByte, we'll have more memory than an '816 system, and a familiar flat addressing model in all addressing modes.
At more than 64kByte, we'll have more memory than a 6502 system.
But even at under 64kB, we have some interesting effects of large zero page, stack and branch distances. And native 16-bit data types.
One architectural twiddle to look into is the single-byte pointer, which will lead nicely to the 65Org32.
Cheers
Ed