The connections are way, way too long, especially the ground connections. From what I can see in the picture, it looks like the ground connection from the oscillator to the processor is nearly a foot long, and from the processor to the VIA is a whopping 20" long! This makes for a lot of unwanted inductance. Start by bringing the black and red vertical wires on the left over to the right about an inch and three quarters, or even running them up the middle, between the ICs. If you really want them on the side, put them up the right side as well. Put a capacitor across the ACIA and one across the VIA also, from the power pin to the ground pin, with connections as short as possible, like you did on the processor and memory.
For some help understanding AC performance and what goes on in the high frequencies involved (not just clock speed, but 100MHz and more, involved in the switching speeds), see the AC-performance chapter of the 6502 primer at
http://wilsonminesco.com/6502primer/construction.html and the references at the bottom of the page, and our sticky topic at
viewtopic.php?f=4&t=2029 .