While I've successfully hand-routed a number of smaller boards, my latest board has about 300 pins (including an 84-PLCC FPGA). The only way I manage to successfully route 'larger' boards is to use X/Y ( see http://www.ami.ac.uk/courses/ami4809_pc ... _imgaj.gif as an example) routing which, while effective, doesn't really look that great IMO. I usually flood-fill the bottom and make that the ground plane which tends to work (reasonably) well.
Anyone have any advice how to 'properly' route other than practice makes perfect? The 84-pin PLCC in particular gave me some headaches. Ironically, SMT boards seem much easier to route but a bitch to solder. Pick your poison I suppose
Yvo