I've had success with perf board, for a simple system, well past your planned speeds.
The 65C02 on this board is clocked at 16mhz. It's co-processor not unlike the one I pictured in my introductory post.
The only things connected to the 6502 are the rom, 2 ram chips and the memory decode GAL. All communication with the host goes via the ADT7130 dual port ram.
I imaging though that's right on the edge of what's possible for this design. I've done 3 boards of this design, the first of which will "only" clock to 14mhz the later 2 will clock at 16.
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File comment: Simple 16Mhz W65C02 on perf board
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File comment: Component side view
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